Kreatech Diagnostics

The proprietary ULS (Universal Linkage System) technology provides the basis for KREATECH’s broad range of labeling applications. ULS labeling is based on the stable coordinative binding properties of platinum to nucleic acids and proteins.

The ULS molecule consists of a platinum complex, a detectable molecule and a leaving group which is displaced upon reaction with the target. This reaction results in a coordinative bond, firmly coupling the ULS to the target. ULS labels DNA and RNA by binding to the N7 position of guanine. In proteins, ULS binds to sulfur and nitrogen containing side chains of methionine, cysteine and histidine. ULS is available coupled to a variety of labels and haptens, including fluorochromes and biotin. The labeling reaction allows a wide range of conditions and produces a highly stable bond.